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Platelet Rich Fibrin

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Platelet Rich Fibrin 

Advanced Platelet Rich Fibrin (A-PRF) is a concentrate of growth factors and other bioactive molecules derived from the patient's own blood. It is prepared from a small amount of blood by centrifugation to separate the platelets and plasma from the red blood cells. The platelet-rich plasma is then further processed to create A-PRF.


The resulting product is a fibrin clot that contains a high concentration of platelets and white blood cells (leukocytes), along with growth factors and other bioactive molecules. A-PRF has been used in many fields such as oral surgery, maxillofacial surgery, plastic surgery, orthopedic surgery, wound healing, and esthetic medicine. A-PRF is considered as an autologous product, which means it is prepared from the patient's own blood, thus it is safe and can be used without any risk of disease transmission or allergic reaction.

How PRF Works

The process begins by drawing a small amount of blood from the patient, typically around 6-8 mL. The blood is then placed in a centrifuge, which spins the blood at high speeds to separate the different components. During the centrifugation process, platelet-rich fibrin (PRF) is generated by separating the platelet-rich plasma (PRP) from the red blood cells and plasma. The PRF is a gel-like substance that contains a high concentration of platelets, growth factors, and other healing substances.


PRF can be used in various medical procedures such as dental implant surgery, bone grafting, gum grafting (to treat gum recession and more.

Once the PRF is obtained, it can be used in a variety of ways depending on the specific medical procedure. It can be used as a gel or a membrane (like a bandaid), and is applied directly to the surgical site or wound to promote healing and tissue regeneration. The platelets in the PRF release growth factors that stimulate the healing process and promote the growth of new blood vessels, bone, and soft tissue.

Additionally, PRF is known to reduce inflammation and pain, and promote the production of new blood vessels. This means that PRF can be used to help speed up the healing process, reduce the risk of infection, and promote the growth of healthy new tissue.

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